400

An in-depth, independent, literature-based study of a current topic in chemistry or biochemistry. Final paper and presentation are required. Graded on a pass/fail basis.

An extension of Biochemistry with an emphasis on advanced theory and methods, including enzyme kinetics, pharmacokinetics, pharmacodynamics, Gibbs free energy calculations and synthetic bio-organic chemistry. Additionally, the specialized biochemistry of several organs, tissues and diseases are discussed. Graded laboratory reports, project presentations and exams are employed to assist students in mastering the fundamental concepts presented during both the lecture and laboratory portions of the course. Lecture and laboratory.

Studies atomic and molecular structure, types of chemical bonding, periodic relationships, typical reactions of inorganic substances, and the modern experimental methods used in inorganic chemistry. Lecture only.

This course is designed to cover many of the topics discussed in Organic Chemistry I and II in more depth. Topics may include the general study of organic reaction mechanisms including Eyring plots, Hammond's postulate, Curtin-Hammett principle, isotope effects and acid-base catalysis; conformational control; stereoelectronics; Hückel molecular orbital theory; pericyclic reactions; aromaticity; free-radical species and reactions; nucleophilic substitutions; eliminations; additions; multi-step synthetic strategies; retrosynthetic strategies; and natural product synthesis. In addition, the student is expected to develop literature research skills by preparing and presenting a project involving the total synthesis of a naturally occurring compound or a topic of current interest. Lecture only.

Studies the theory and practice of modern instrumental methods of chemical analysis. Methodology includes spectrophotometric, chromatographic, electroanalytical and nuclear techniques. Additionally, students are required to retrieve scientific information from primary, secondary and tertiary literature sources. Lecture and laboratory.

Pre- or corequisite: CHE 433L (with a grade of "C" or better). This course provides a comprehensive overview of chemical methods and techniques commonly used in the analysis of forensic evidence. Topics include 1) drugs of abuse, 2) absorbance methods and color tests, 3) fluorescence and chemilluminescence methods, 4) extractions and separations, 5) gas chromatography, 6) high performance liquid chromatography, and 7) mass spectrometry. The course is focused on forensic analytical methods, with particular emphasis on analysis of drugs of abuse, as well as interpretation of data. Lecture.

Pre- or corequisite: CHE 435L (with a grade of "C" or better). Focuses on the application of methods discussed in Forensic Chemistry I to toxicology. Additionally, forensic methods for trace evidence analysis are introduced. Topics covered include 1) immunoassay, 2) forensic toxicology analyses of urine, blood, and alternative matrices, 3) pharmacokinetics and metabolism, 3) blood-alcohol analyses, 4) postmortem toxicology, 5) fundamentals of trace evidence analysis, 6) trace evidence analysis methods, and 7) analysis of fibers, paint chips, and gunshot residue. Lecture.

Provides an outline of the key components of QA/QC. The need to produce sound scientific data using appropriate standards and controls, written procedures and method validation are explored. The key principles in any QA/QC laboratory program with reference to the FDA, EPA and ISO guidelines together with specific examples from different specializations in those particular fields are described. Can be used to satisfy the CHE 499 requirement in chemistry. Lecture only.

Pre- or corequisites: CHE 354, CHE 355L. Covers current spectroscopic methods for organic structure determination. Topics include elemental analysis, liquid-chromatography-tandem mass spectrometry (LC-MS/MS), infrared spectroscopy and nuclear magnetic resonance spectroscopy and their use in organic structure determination. Students are expected to develop literature research skills by preparing and presenting a project involving the determination of the molecular structure of a naturally occurring compound.

Qualified students in junior year choose project subject in consultation with chemistry faculty member. Requires laboratory research and a written report presented to and reviewed by the chemistry faculty. Students must also make an oral presentation of the results of their work. May be repeated for a total of 4 credit hours. Graded on a pass/fail basis.

Provides practical experience in chemistry-related programs in a firm or agency under the supervision of faculty and firm representatives. May be accomplished on a part-time basis and may be repeated for a total of 4 credit hours. Graded on pass/fail basis.

Consists of an internship in a forensic laboratory or equivalent where the student conducts analyses in a specialization area of interest. The products of this experience are a presentation at a professional conference and/or campus seminar, plus a written paper. Students must apply for this internship one semester in advance. Graded on a pass/fail basis.

Provides practical experience in forensic science-related programs in a firm or agency under the supervision of faculty and agency representatives.

This course is an introduction to techniques in animal tissue culture, the science of growing individual cells in vitro (outside the original animal). These techniques provide the basis for carrying out diverse research projects in the medical research, clinical and biotechnology fields. This laboratory-intensive course provides hands-on experience in cell growth and propagation, subculture, cloning, cryopreservation and proper aseptic technique. Lecture and laboratory.

This course provides a comprehensive overview of the basic principles of toxicology and the practical aspects of forensic toxicology. The toxic agents most commonly resulting in legal problems in our society and the process by which our judicial system is aided by scientific investigation will be discussed. Other topics include the biotransformation of toxicants, chemical carcinogenesis, mutagenesis, teratogenesis, systemic toxicology, the biochemistry of poisons and the control of poisonous material. Laboratory investigations involve toxicological analysis by microscopy, thin layer chromatography, spot testing, gas-liquid chromatography, mass spectrometry and infrared analysis. Can be used to satisfy the CHE 499 requirement in chemistry. Lecture and laboratory.

A lecture and/or laboratory course offered at the discretion of the chemistry faculty. Subject may be chosen from theoretical and/or practical applications in biochemistry, analytical, inorganic, physical or organic chemistry.